What is the meaning for us today of the Enlightenment? Of positivism and of the social sciences? How should we envision the revolutions in physics, biology and the neorosciences? What are the future roles of ideology and politics, faced with the challenge of the present religious come-back? Is the notion of progress still relevant? Can a fundamental, universal anthropology be established? In their discussions, the authors Debray from a literary point of view, and Bricmont from a scientific one meet, confront and defy each other. In the course of their talks, they summon theory and practice, past and present, history and current events, facts and their own personal convictions, to give the reader a brilliant lesson against the dominant mood of nihilism. Régis Debray heads the European Institute of the History and Science of Religion. He is the author of numerous works, including God, An Itinerary. Jean Bricmont teaches theoretical physics at the University of Louvain. He is the co-author with Alan Sokal of Intellectual Impostures.